In vitro activities of the glycylcycline GAR-936 against gram-positive bacteria.
نویسندگان
چکیده
The in vitro activities of GAR-936, the 9-t-butylglycylamido derivative of minocycline, were compared with those of doxycycline, minocycline, and tetracycline against 527 gram-positive clinical isolates. GAR-936 inhibited all strains, including those resistant to other tetracyclines, at concentrations of </=2 microg/ml, except two strains of JK diphtheroids for which the MIC was 4 microg/ml.
منابع مشابه
Activities of the glycylcycline tigecycline (GAR-936) against 1,924 recent European clinical bacterial isolates.
The in vitro activities of tigecycline against 1,924 clinical isolates were examined. The new glycylcycline exhibited excellent activity against all gram-positive cocci (MICs at which 90% of the isolates tested were inhibited [MIC(90)s], <or=1 microg/ml). In addition, it was also very potent against most members of the Enterobacteriaceae, with most MIC(90)s being <or=2 microg/ml. Among the nonf...
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1. Livermore DM. Tigecycline: what is it, and where should it be used? J Antimicrob Chemother 2005; 56: 611–4. 2. Tenover FC, Arbeit RD, Goering RV et al. Interpreting chromosomal DNA restriction patterns produced by pulsed-field gel electrophoresis: criteria for bacterial strain typing. J Clin Microbiol 1995; 33: 2233–9. 3. Clinical and Laboratory Standards Institute. Performance Standards for...
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عنوان ژورنال:
- Antimicrobial agents and chemotherapy
دوره 44 8 شماره
صفحات -
تاریخ انتشار 2000